An enhanced ’off-label’ drug anti-cancer protocol?

An enhanced ’off-label’ drug anti-cancer protocol?

Some people want to create an off-label or repurposed drug protocol; others understand that you may need conventional therapies, and natural compounds as well; here CANCERactive creates an easy to understand integrative anti-cancer protocol with the potential to fight a cancer and its stem cells. It's a place to start.

The CANCERactive Protocol

I am regularly asked questions such as: “Chris, you’ve done a great job and got my cancer stable. It has been stable for more than two years. Can we do anything now to reduce it further? What about off-label drugs?” (writes Chris Woollams)

Now, I first suggested a patient used off-label drugs back in about 2007/2008, and I also wrote an article about ‘Building an off label drug protocol', back then. It’s an article we have updated many times, as more research comes in.

Go to: Building an off-label drugs protocol for cancer?

In it, right up front, I ask an important question: "Why would anyone in their right mind want to build an off-label drugs protocol?" Surely, you want the best compound for the job - and by 'best' I mean everything from the most effective to the least side-effects.

Take Berberine vs Metformin. Berberine is a herb; Metformin a drug. We have a review on metformin HERE. The latter has several studies about liver issues, and tainted product. In Melanoma patients with a BRAF mutation Metformin can accelerate the cancer.

Both cut blood sugar. Berberine does it better - we compared them using people with diabetes. Both have research on correcting AMPK, berberine has considerably more. Berberine attacks microbes and reduces inflammation in the body; Metformin does neither. Berberine cuts homocysteine, which builds up before cancer and other chronic illnesses; Metformin increases it (4) and with long-term use it can even contribute to neuropathy. Which one am I going to use?

Yes, we do suggest Atorvastatin, but we know a small daily aspirin helps it produce better results; and we use CoQ10 with it to prevent myopathy (The Mayo Clinic states that this is important too) and to increase the longevity of effectiveness from an average of only four years extra survival (which was found in an Australian study on women with breast cancer, colorectal and melanoma).

We also understand Atorvastatin's limitations - for example it offers zero benefit with certain cancers like lymphoma (there's a meta-analysis concluding nil benefit), and little with brain cancer.

But if your cholesterol is lower than 4.5 we will use lycopene, phytosterol foods and Honokiol, which will do a safer and better job at blocking angiogenesis and cancer spread, while attacking cancer stem cells, E. coli and blocking glutaminase (which converts amino acid glutamine, into the fuel glutamate) as well. We sometimes use all natural C-statin too.

We suggest Propranolol for ovarian cancer because there’s research from MD Anderson with high grade serous, but we use Ashwagandha for cancers where there's no research on the drug as, again, it can have unwanted side-effects. We almost always use Turmeric rather that Dipyridamole; and Oregano oil (or Artemisinin) rather than Itraconazole.

And we never use Doxycycline because we understand from the HUMAN MICROBIOME PROJECT that you cannot build a healthy body without first having a healthy gut and Doxycycline is a bog standard antibiotic and ‘scars’ the gut according to research. If we want to tackle cancer stem cells, there’s Niclosamide, retinoic acid and Ivermectin (the safest drug the FDA have ever approved, as they stated). Plus about 15 natural compounds including genistein, turmeric, resveratrol, sulforaphane and green tea.

But let's be clear. You do need to attack both the cancer cells AND the cancer stem cells, or there will always be a concern that the stem cells will cause recurrence.

Let’s leave the last thought on this to Dr Young S. Kim, head of Cancer and Nutrition at the National Cancer Institute. Kim buys in all the research studies. She has her own list for preventing recurrence from all the NCI research. It includes sulforaphane, turmeric, genistein, vitamin A (as in Retinoic Acid), vitamin E (complete), theanine, piperine (black pepper) and EGCG (green tea).

So with this in mind, is there an off-label protocol that might help and which you could reinforce with natural compounds and diet? After all, that’s how Professor Ben Williams beat his GBM - I think of it as four concentric circles - he took conventional drugs, surrounded by off-label drugs, surrounded by natural compounds, surrounded by Lifestyle changes in diet, exercise and more.

So let’s take the drug he used, Mebendazole, which doesn’t have as much research on as many cancers as Fenbendazole, and start there. Doctors and oncologists could not prescribe Fenbendazole - it is not licensed for humans; they’d be struck off.

They are both antihelminthic drugs, as are Ivermectin and Niclosamide. You can't use Niclosamide at the same time as Fenbendazole, but you could use Fenbendazole, Mebendazole and Ivermectin together. (This can be obtained on line and could be very strong). But let's continue only with FenBen as an illustration -

Building a protocol around Fenbendazole?

Joe Tippens, an avid researcher who was given three months to live, decided to try Panacur with the agreement of his American medical consultant. Joe took a combination of nutrients to support the main ingredient, Fenbendazole, while deciding not to change his diet, when his NSCLC was in the final stages. It worked!

* Let’s start by looking at Joe Tippens' original protocol for Fenbendazole

  • 1 gram granules of canine drug ‘Panacur C’, these contain 222 mg of fenbendazole; taken 3 days on, 4 days off

  • Vitamin E Succinate (800 IU daily)

  • Curcumin (600mg daily)

  • CBD oil (25mg per day)

* What else could we do?

i) From our 20+ years of anti-cancer experience, we would suggest patients use ''total' complete vitamin E with all 4 tocopherols and all 4 tocotrienols, instead of the succinate version. We also think that the turmeric/curcumin dose should be 2.5 gm; alongside piperine (black pepper). 

ii) We suggest patients add both Berberine (3 x 500 mg) and Quercetin (2 x 500 mg) to enhance the anti-cancer, sugar reducing and antiinflammatory effects. We want fasting blood sugar levels to be around 4.0 mmol/dL (76 mg/dL) to 4.5 maximum to restrict the cancer's ability to feed.

iii) Depending upon the cancer, we suggest either Cimetidine or Loratadine (US: Claritin) to restrict cancer spread.

iv) We like Ashwagandha (3 x 500 mg) to reduce stress hormones and inflammation; And, yes, we do use CBD oil (and sometimes Frankincense topically, or CBD and Boswellia (2 x 200-250mg) orally.

v) We also like to use Melatonin (20 mg before bed) to aid sleep, correct cancer cells, reduce cancer stem cell levels and lower growth hormone. Always sleep in a room that is completely dark and EMF-free. We often add Indole 3 carbinol to aid those effects. But you must go outdoors for 2 hours a day - it's a little-known fact that you make up to 100 times more melatonin by day

vi) We suggest patients ensure their oxygen levels are 99% (taken after sitting for at least 45 minutes), their vitamin D levels are 125 nmol/L.

vii) We want your cholesterol levels to be around 4.0-4.8 mmol/L (155 - 170 mg/dL). If you are already below 4.5 we would use Lycopene (60 mg), phytosterols and Honokiol (600 mg) plus Dandelion (1500 mg); if above 4.5-4.8, we would use Atorvastatin or Simvastatin, with a small aspirin (to enhance action) and CoQ10 (100-200 mg) to protect you. We still use Honokiol and Dandelion for their strong anti-metastatic effects (Sometimes we add modified citrus pectic depending on the cancer and research available).

viii) We often suggest patients add in Retinoic Acid (concentrated vitamin A). In the Accutane form it was used by Prof Ben Williams to kill his brain cancer stem cells, but some doctors won't prescribe Accutane due to potential liver issues. Retinoic acid attacks cancer stem cells. Fenbendazole doesn’t.

ix) We almost always suggest people use a green juice or smoothie. Natural kale, broccoli, cucumber, celery, plus a 'Supergreens' mix containing chlorella, wheat grass and sea moss/kelp for some iodine. Never put fruit in this; you will get too big a sugar hit. But we always use five or more grams of ginger root in a pint of juice - wonderfully anti-inflammatory, kills microbes, and cuts blood fats and blood sugar. The green juice promotes oxygen levels, is an oestradiol blocker, and allows you to make and regulate glutathione, the number two antioxidant, called up by Melatonin to help it in its work reducing free-radicals in your cells.

x) We would definitely want patients to employ a Mediterranean lifestyle - diet, exercise, outdoors for 2-3 hours a day, good sleep and a sense of community, fun and involvement. 95 research studies and voted the healthiest diet, and the healthiest plant-based diet in the world for six years in a row. As we've always shown - it protects and corrects.


See - Rainbow Diet - it's a healthy lifestyle not just a diet.


xi) We would always want patients to rebuild their microbiome. See reference (1) to rebuild yours starting today.


* Ignore this at your peril. We have US research that people who take just 2 drugs for 4 rounds and only two weeks of antibiotics have still lost 73% of their microbiome even after one year!!!


See - rescuing patients after drugs and antibiotics


* There's very clear research that women who don't have a healthy microbiome with breast cancer have much lowered survival that those who do.


See - an unhealthy gut worsens breast cancer survival.


xii) We would want you to understand the importance of your mind and believing that you can beat cancer. See reference (2).




There you have it. A CANCERactive enhanced off-label drugs protocol. 12 steps towards building a healthier body. That is, after all, the end goal. A healthy new you.


We do often add Low Dose Naltrexone - 0.5 mg rising to 4.5 mg, with CBD; it is a good immune booster and can reduce pain. This depends upon circumstances.


If you noticed we say words like 'sometimes' and 'usually', it is because there is an increasing amount of research on off-label drugs and you need to understand:


* One size does not fit all - the same 4 drugs are not right for everyone

* Some commonly used off-label drugs, can sometimes make matters worse - metformin has research on exactly this with TNBC.


You need help from someone who understands your cancer AND has put a lot of time and effort into researching each of these off-label drugs. Remember, they are drugs. They can interact negatively especially with other drugs; they might not be right for you or your cancer.





p53 deficiency? You should also find out if you are p53 deficient See reference (3). If you are, you might not need an off-label drug protocol per se. Your cancer might be linked to a deficiency - a turned off p53 gene. If so, you might be better taking a more natural metabolic approach using a combination of natural compounds and an off label drug that can turn your p53 gene back on. As we said above: Talk to an expert who understands your wider options.


Go to: A metabolic Therapy for cancer - correcting p53 deficiency





1. Heal your gut now -

2. How your mind can help you fight cancer - 

3. TP53, p53 and cancer -

4. Association of metformin, elevated homocysteine, and methylmalonic acid levels and clinically worsened diabetic peripheral neuropathy; Daryl J Wile, Cory Toth; Diabetes Care 2010



  Approved by the Medical Board.  Click Here



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