Melatonin shown to have strong epigenetic benefits in breast cancer

Melatonin shown to have strong epigenetic benefits in breast cancer

Melatonin has been shown to have important epigenetic (cancer-correcting) benefits in breast cancer, being capable of regulating the growth and spread of breast cancer, according to a review of existing research by scientists in Turkey. 

Melatonin is produced by the pineal gland about 45-60 minutes are falling asleep in a darkened room. Dankness causes its production.  But people who have disturbed sleep patters are known to develop more oestrogen driven cancers such as breast and prostate, because melatonin is an oestrogen regulator. Long haul air hostesses, night shift workers and party animal all have an increase in cancer risk.

Also, people with poor sleeping habits should consider whether their bedroom is affected by light, or EMFs as both reduce melatonin production. Eye shades are helpful.

Even people exposed to high levels of blue light (computer screens, mobile phones) during the day have poorer sleep patterns.

Go Here to: Learn how to take control of your oestrogen levels.

In a 2009 research review ‘The role of melatonin in epigenetic regulation of breast cancer’ scientists Ahmet Kormaz, Sanchez-Barcelo, Tan and Reiter of the School of Medicine, Ankara, Turkey, looked at ‘the oncostatic properties of melatonin as they directly or indirectly involve epigenetic mechanisms of cancer with a special focus on breast cancer.

Five lines of evidence suggest that melatonin works via epigenetic processes:

(1) Melatonin influences transcriptional activity of nuclear receptors (ERalpha, GR and RAR) involved in the regulation of breast cancer cell growth;

(2) Melatonin down-regulates the expression of genes responsible for the local synthesis or activation of estrogens including aromatase, an effect which may be mediated by methylation of the CYP19 gene or de-acetylation of CYP19 histones;

(3) Melatonin inhibits telomerase activity and expression induced by either natural estrogen or xenoestrogen;

(4) Melatonin modulates the cell cycle through the inhibition of cyclin D1 expression;

(5) Melatonin influences circadian rhythm disturbances dependent on alterations of the light/dark cycle (i.e., light at night) with the subsequent deregulation of PER2 which acts as a tumor suppressor gene.

Melatonin can be bought over the counter in the USA and Canada but can only be prescribed, and then at a small dose of maximum 3 mg, by Doctors in Europe.

the Medicinal dose according to research is 20 mg.

Go to: Melatonin improves chemotherapy and radiotherapy effectiveness, increases survival; reduces side-effects


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