Scientists from the Howard Cancer Center in Washington DC, have found anticancer compounds in Muscadine red grape skins can prevent and even stop metastatic prostate cancer.
The researchers found (1) that by using an extract of muscadine grape skins (MSKE) - muscadine is a type of grape native to the southern United States but can be grown in the U.K. - on prostate cancer cells, it stopped the cancer cells from growing even after they had spread to other parts of the body (writes Gilly Bertram).
The researchers explained that the MSKE achieves this by targeting a cell (PC-3) and a protein (Hsp40) both of which are involved with the movement of the cancer from one part of the body to another.
The team concluded that MSKE could be investigated further as a potential treatment for metastatic prostate cancer.
Chris Woollams, former Oxford University Biochemist and a founder of CANCERactive added, “Yet again, we are seeing the power of polyphenols against cancer - polyphenols are found in a wide variety of plants, herbs and spices – turmeric (curcumin), green tea (EGCG), pomegranate, red grape skins (resveratrol), apples (quercitin), hazelnuts, cherries and raspberries (ellagitannins) and even filtered coffee and cocoa.
Back in 2010 research in the FASEB journal (2) showed in vitro and in vivo that polyphenols in red wine and green tea blocked the SphK1/S1P signaling pathway, essential to prostate cancer growth and metastasis. We now know polyphenols can play a part in restricting breast cancer, colon cancer and several others. Potentially, polyphenols can defeat cancer.”
Go to: Green tea, chronic illness and cancer
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References
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348279/
- L. Brizuela, A. Dayon, N. Doumerc, I. Ader, M. Golzio, J.-C. Izard, Y. Hara, B. Malavaud, O.Cuvillier. The sphingosine kinase-1 survival pathway is a molecular target for the tumor-suppressive tea and wine polyphenols in prostate cancer. The FASEB Journal,2010; DOI: 10.1096/fj.10-160838