Topotecan Hycamptin

Topotecan Hycamptin

This patient-friendly article is about chemotherapy drug, Topotecan (Hycamptin) which is a chemotherapy drug primarily used to treat ovarian cancer, but also small cell lung cancer and acute myeloid leukaemia

It is a topoisomerase 1 inhibitor, which works by blocking the topoisomerase 1 enzyme, which helps to separate and repair the DNA in cells when they divide.  Blocking the action of this enzyme damages the DNA and so the cells cannot continue to grow. 

Topotecan is administered through a drip intravenously.

Side effects can include: fatigue, greater risk of infections, anaemia, bruising and bleeding, nausea and vomiting, temporary hair loss or thinning, diarrhoea or constipation, mouth ulcers.

Approved by

the Medical Board. 

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Go to: 10 ways to improve your chemotherapy success and reduce side-effects

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Go to: Return to the CANCERactive drug list


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